Studies 437 and 438 Integrated ADV 10 mgALT Elevations > 10 x ULN 48-96 Weeks

ADV?ADV ADV?PLB

(n=164) (n=111)

ALT > 10 x ULN 6% 25%

ALT > 10 x ULN with:

Bilirubin ? 2.5 mg/dL and ə% 3%

? 1 mg/dL above baseline

Albumin < 3 g/dL 0% 0%

PT prolonged ? 1.5 sec 0% 0%

above ULN

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