Studies 437 and 438 Key Inclusion Criteria

• Documented HBsAg positive for ? 6 months

• Compensated liver disease

• Adequate renal function

• HIV, HCV, and HDV seronegative

• Liver biopsy

HBeAg–

? 105 copies/mL

? 1.5–15

HBeAg+

? 106 copies/mL

? 1.2–10

HBV DNA

ALT x ULN

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