Preclinical Pharmacology and Toxicology
Antiviral activity and safety in DHBV, WHV, and transgenic mice expressing HBV
- Reduced serum viremia in all models
- In DHBV model, reduced cccDNA in liver and DHBV DNA/viral antigen in bile duct epithelial cells
- No adverse effects in woodchucks
Dose proportional PK of adefovir following oral administration of adefovir dipivoxil
Eliminated as unchanged adefovir in urine
Kidney principal target organ