Table of Contents
Study Designs for Acute Otitis Media: What can each design tell us?
Current state of affairs
Why do some trials fail to detect differences among treatments?
Should TAPS be performed?
Single TAP at baseline
Fundamental question regarding the utility of a microbiologic endpoint
Agency for Health Research Quality Evidence Report (2001): Management of Acute Otitis Media
Randomized, double-blind, placebo-controlled trials
Advantages and disadvantages of placebo-controlled trials
Non-inferiority design without TAPS
Non-inferiority design with baseline TAP
Non-inferiority design with repeat TAPS
Which design to use?
What does each design tell us?
Author: george rochester