Study Designs for Acute Otitis Media: What can each design tell us?

7/19/02


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Table of Contents

Study Designs for Acute Otitis Media: What can each design tell us?

Outline

Population Studied

Current state of affairs

Why do some trials fail to detect differences among treatments?

Should TAPS be performed?

Single TAP at baseline

Repeat TAPS

Fundamental question regarding the utility of a microbiologic endpoint

Agency for Health Research Quality Evidence Report (2001): Management of Acute Otitis Media

Randomized, double-blind, placebo-controlled trials

Advantages and disadvantages of placebo-controlled trials

Non-inferiority trials

Non-inferiority design without TAPS

Non-inferiority design with baseline TAP

Non-inferiority design with repeat TAPS

Which design to use?

What does each design tell us?

Summary

Credits

Author: george rochester