Table of Contents
ALEFACEPT
Proposed Indication for Alefacept
Agenda
Biogen Consultants
Chronic Plaque Psoriasis
Patient Perspective: Moderate to Severe Psoriasis
Non-Cutaneous Burden of Disease
Current Therapies
Immunopathology of Psoriasis
Leukocyte Populations
Memory T Cells are Derived from Naïve T Cells
Alefacept: A Fully Human Fusion Protein
Alefacept Mechanism of Action
Alefacept Targets Memory T Cells
Toxicology Program
Toxicology Program: Results
Clinical Program
Ongoing Clinical Development
Regulatory History
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