Measures in Current and Proposed Trials
NIS-LL plus 2-10 additional tests
NIS-LL plus 7: VPT, RR with deep breathing, 5 NCV (peroneal CMAP, MNCV, MNDL), tibial nerve (MNDL) and sural (SNAP)
Rochester Diabetic Cohort: .35 change no DPN, .85 change with DPN yearly; NI-LL plus 7 correlates with other microvascular complications
Protocol in Nathan I, II trials (lipoic acid)
Diabetes Care 22:1479-1486, 1999