Aldose Reductase: ZenerstatPhase III Trial

Entry criteria : same as Phase II

Primary: Composite ranked score for median forearm sensory, peroneal motor and sural sensory CV plus composite ranked score of QST for vibratory and cool perception

Secondary: individual NCV, F waves, sural and median amplitudes; MDNS; Health-Related QOL (Symptoms, Health Survey

Discontinued due to renal toxicity

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