Drug Interaction Studies
Theophylline interaction
- PK/PD in chronic theophylline users
CYP 3A induction
- PK interaction of pleconaril 400 mg TID x 5 days and oral midazolam to assess duration of induction
- Two cycle OC PK/PD interaction study of pleconaril 400 mg BID x 3 weeks to assess maximum PK induction and PD effects (ongoing)