The Chemoprevention of Sporadic Colorectal Cancer Issues Surrounding a Benefit/Risk Analysis in Clinical Trials

3/19/02


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Table of Contents

The Chemoprevention of Sporadic Colorectal Cancer Issues Surrounding a Benefit/Risk Analysis in Clinical Trials

Overview of Presentation

PPT Slide

Benefits for Different Uses

Efficacy

Is Adenoma Recurrence a Useful Surrogate for CRC Risk?

PPT Slide

Screening and Surveillance Colonoscopy (As Therapy)

Factors Influencing Efficacy

Safety

Safety: Study Population

PPT Slide

Issues Surrounding Safety

PPT Slide

Number Needed to Treat (NNT)

Ability to Detect Drug Toxicity: Low Background Rate

Ability to Detect Drug Toxicity: High Background Rate

Benefit/Risk

FDA Approved Chemopreventive Agents

PPT Slide

Unresolved Issues

Author: Mark Avigan