Table of Contents
The Chemoprevention of Sporadic Colorectal Cancer Issues Surrounding a Benefit/Risk Analysis in Clinical Trials
Overview of Presentation
PPT Slide
Benefits for Different Uses
Efficacy
Is Adenoma Recurrence a Useful Surrogate for CRC Risk?
PPT Slide
Screening and Surveillance Colonoscopy (As Therapy)
Factors Influencing Efficacy
Safety
Safety: Study Population
PPT Slide
Issues Surrounding Safety
PPT Slide
Number Needed to Treat (NNT)
Ability to Detect Drug Toxicity: Low Background Rate
Ability to Detect Drug Toxicity: High Background Rate
Benefit/Risk
FDA Approved Chemopreventive Agents
PPT Slide
Unresolved Issues
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