Table of Contents
Perspectives in Chemometrics
Where are we starting from
PPT Slide
First things:
General classes of chemometric methods
ASTM E1655-97
What separates the ASTM document from the needs of the pharma industry?
What separates the ASTM document from the needs of the pharma industry?
> USP chapter: Near-infrared Spectrophotometry
What technologies have been or may be used for PAT?
PPT Slide
PPT Slide
So, what steps do we need to take to ensure success?
... success? (cont.)
On-line or at-line determination of composition issues
Calibration
Maintenance of calibration
Maintenance of calibration (cont.)
Pattern recognition / classification techniques
Multivariate statistical process control
Multivariate statistical process control (cont)
Sampling issues
Sampling issues (cont.)
Software issues
Software issues (cont.)
Process control
For example
What was learned?
What was learned? (cont.)
What can ease this in the future?
What are other issues/approaches?
|