Table of Contents
Applications and benefits of PAT
Agenda
No sampling No operator exposure Accurate end point Control of impurities
Focused Beam Reflectance Measurement
Crystal size change during formation
Endoscope picture inside crystalliser
Pan Dryer
PPT Slide
NIR on a fluid bed dryer - granule drying
Glatt Multi-Cell Fluid Bed Dryer
On-Line analysis of blending
On- line NIR bin blender
PPT Slide
Saccharin Specific Absorption
Magnesium Stearate Specific Absorption
Absorbance of Blend Components (Step 1)
Saccharin Uniformity (Step 1)
Magnesium Stearate Uniformity (Step 2)
NIR Instrument in production plant
Blender Filling
Online Monitoring of Aromatic Absorption
Online Monitoring of Aromatic Absorption
On-line blending - benefits
NIR Tablet Transmission Device
Tablet core potency - blend segregation in the bin
Automated tablet analysis
Bruker NIR Transmission Head
Absorbance of active tablets Vs placebos
NIR transmission Vs conc in tablets 0.1% - 2.0%
On-line tablet cores - benefits
Microscopic View of Dosage Form
The Future…..
Benefits of Improved Control
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