Cure Rate Models and Adjuvant Trial Design for ECOG Melanoma Studies in the Past, Present, and Future

3/8/02


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Table of Contents

Cure Rate Models and Adjuvant Trial Design for ECOG Melanoma Studies in the Past, Present, and Future

Outline

Cure Rate Models

Plateau for E1684 Relapse-Free Survival

Plateau for E1684 Overall Survival

Plateau for E1690 Relapse-Free Survival

Assumptions for Cure Rate Model (1)

Assumptions for Cure Rate Model (2)

Properties of Cure Rate Model

Statistical Design for E1684

Statistical Design for E1690

Design Assumptions for E1690 (1)

Design Assumptions for E1690 (2)

Design Assumptions for E1690 (3)

Sequential Monitoring for E1690

Sequential Monitoring Plan for E1690

Statistical Design for E1694

E1694 Design Assumptions (1)

E1694 Design Assumptions (2)

E1694 Design Assumptions

E1694 Sequential Monitoring Plan for RFS

E1694 Sequential Monitoring Plan for OS

Statistical Design for E1697

E1697 Statistical Design Assumptions (1)

E1697 Statistical Design Assumptions (2)

E1697 Statistical Design Assumptions (3)

E1697 Sequential Monitoring Plan for RFS

E1697 Sequential Monitoring Plan for OS

Conditional Power Considerations for E1697 (1)

Conditional Power Considerations for E1697 (2)

Noninferiority Designs

Statistical Design for E1601 (1)

Statistical Design for E1601 (2)

Statistical Design for E1601 (3)

Statistical Design for E1601 (4)

Sequential Monitoring Plan for E1601 (1)

Sequential Monitoring Plan for E1601 (2)

Sample Sizes Under Several Design Scenarios to Achieve 95% Power

Future Trial Designs

Future Trial Designs

Bayesian Design and Monitoring (1)

Bayesian Design and Monitoring (2)

Bayesian Design and Monitoring (3)