Table of Contents
Cure Rate Models and Adjuvant Trial Design for ECOG Melanoma Studies in the Past, Present, and Future
Outline
Cure Rate Models
Plateau for E1684 Relapse-Free Survival
Plateau for E1684 Overall Survival
Plateau for E1690 Relapse-Free Survival
Assumptions for Cure Rate Model (1)
Assumptions for Cure Rate Model (2)
Properties of Cure Rate Model
Statistical Design for E1684
Statistical Design for E1690
Design Assumptions for E1690 (1)
Design Assumptions for E1690 (2)
Design Assumptions for E1690 (3)
Sequential Monitoring for E1690
Sequential Monitoring Plan for E1690
Statistical Design for E1694
E1694 Design Assumptions (1)
E1694 Design Assumptions (2)
E1694 Design Assumptions
E1694 Sequential Monitoring Plan for RFS
E1694 Sequential Monitoring Plan for OS
Statistical Design for E1697
E1697 Statistical Design Assumptions (1)
E1697 Statistical Design Assumptions (2)
E1697 Statistical Design Assumptions (3)
E1697 Sequential Monitoring Plan for RFS
E1697 Sequential Monitoring Plan for OS
Conditional Power Considerations for E1697 (1)
Conditional Power Considerations for E1697 (2)
Noninferiority Designs
Statistical Design for E1601 (1)
Statistical Design for E1601 (2)
Statistical Design for E1601 (3)
Statistical Design for E1601 (4)
Sequential Monitoring Plan for E1601 (1)
Sequential Monitoring Plan for E1601 (2)
Sample Sizes Under Several Design Scenarios to Achieve 95% Power
Future Trial Designs
Future Trial Designs
Bayesian Design and Monitoring (1)
Bayesian Design and Monitoring (2)
Bayesian Design and Monitoring (3)
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