Prevention of Emergence of Resistance: A Pharmacodynamic Solution

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Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

The Team N. L. Jumbe, A. Louie, W. Liu,V. Tam, T. Fazili, R. Leary, C. Lowry, M.H. Miller and G. L. Drusano

S. pneumoniae outcome studies

P. aeruginosa outcome studies

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

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Mean Parameter Estimates of the Model.

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

PPT Slide

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Study Design: Mouse Thigh Infection Model- Ciprofloxacin Studies [50mg/kg BID ~ AUC/MIC 100:1]

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

PPT Slide

Mean Parameter Estimates of the Bacterial Growth/Kill Model.

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution P. aeruginosa - Prevention of Amplification of Resistant Subpopulation

Prevention of Emergence of Resistance: A Pharmacodynamic Solution P. aeruginosa - Prevention of Amplification of Resistant Subpopulation

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution Multiple Bacterial Populations Do Make a Difference!

Prevention of Emergence of Resistance: A Pharmacodynamic Solution P aeruginosa

Prevention of Emergence of Resistance: A Pharmacodynamic Solution K. pneumoniae

Prevention of Emergence of Resistance: A Pharmacodynamic Solution MSSA

Prevention of Emergence of Resistance: A Pharmacodynamic Solution MRSA-CS

Prevention of Emergence of Resistance: A Pharmacodynamic Solution MRSA-CR

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

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Author: George Drusano