Study Design Issues
MRSA is seldom eradicated quickly, and improvements in activity could yield shorter T-erad
Once established, this organism will persist in blood and soft tissues, despite therapy
Weak antimicrobial action (vancomycin) keeps the patient from death, but dissemination continues to foreign bodies, bone, heart valves, etc.
Accept only MRSA positive patients on vanco for at least 5 days with continued CX positive
- Enroll pts who continued on vanco for retrospective controls
- Enroll pts who have vanco dose increased (additivity control) and follow for changes in time to eradication
- Enroll pts who have same vanco dose but add another ABX (synergy test)