MRSA: Issues With Appropriately Dosed Vancomycin?
MRSA MICs are usually 0.5 to 1.0 mcg/ml
- Slow killing of organisms in vitro and in vivo
- Recent MICs are 2.0 mcg/ml, a 2-4 fold loss of activity
MRSA MBCs are increasingly 4-32 mcg/ml
- Staphylococci that are not yet VISA or VRSA, but no longer responding to vancomycin
- Slow cidal..and getting progressively slower?
Protocol Study; Find these cases and study them using PK/PD; offer solutions while vancomycin is still in the mix of options