ICS Systemic Effects: Ocular

• CAVEATS:

  • Epidemiologic studies not RCT
  • ICS in general, not FP specifically
  • All cataracts not just PSC

• Australian study (Cumming, NEJM 1997)

  • ICS users age 49 - 82 years
  • 2-fold ? in PSC, further ? with cumulative lifetime dose
    

• Canadian study: (Garbe, NEJM 1998)

  • ICS-users age ? 70 yrs with ? 3 years
  • 3-fold ? in cataract extraction, dose response

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