ICS Systemic Effects: Bone (2)
LHS II showed decline in BMD over 3 years:
- Lumbar spine (p=0.007), N=328
- Femur (pɘ.001), N=359
Asthma:
- Israel, NEJM 2001; 3-yr. prospective cohort study of pre-menopausal women ? dose-related ?BMD at hip
- Wong, Lancet 2000; cross-sectional study of young adults, mean exposure 6 yrs? cumulative dose-related decrease in BMD at hip and LS
IMPORTANT CAVEATS:
- Different Moiety, Formulation (TAA vs. FP)
- Different Populations