Table of Contents
PPT Slide
Preclinical Evaluations
Preclinical Evaluations Toxicology/Biocompatibility
Preclinical Evaluations/Induction of Bone
FDA Questions
FDA Questions
Pharmacokinetics/Pharmacology
Preclinical Evaluations/Carcinogenicity
Planned Additional Studies
FDA Questions
Antibody experiments
Human antibody findings
FDA Questions
BMP-2 Knockout Experiments
BMP Knockout mice
Hypothetical fetal expression/restimulation of maternal immune response
Reproduction/Teratology
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