Preclinical Evaluations

1/14/02


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Table of Contents

PPT Slide

Preclinical Evaluations

Preclinical Evaluations Toxicology/Biocompatibility

Preclinical Evaluations/Induction of Bone

FDA Questions

FDA Questions

Pharmacokinetics/Pharmacology

Preclinical Evaluations/Carcinogenicity

Planned Additional Studies

FDA Questions

Antibody experiments

Human antibody findings

FDA Questions

BMP-2 Knockout Experiments

BMP Knockout mice

Hypothetical fetal expression/restimulation of maternal immune response

Reproduction/Teratology

Author: plh