Summary of InFUSE™ Bone Graft Preclinical and Pilot Clinical Studies with Interbody Spinal Fusion Devices Scott Boden, M.D. Professor of Orthopaedic Surgery Director, The Emory Spine Center Emory University School of Medicine

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Summary of InFUSE™ Bone Graft Preclinical and Pilot Clinical Studies with Interbody Spinal Fusion Devices Scott Boden, M.D. Professor of Orthopaedic Surgery Director, The Emory Spine Center Emory University School of Medicine

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rhBMP-2/ACS vs Autograft

rhBMP-2/ACS vs Autograft

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Biomechanical Test Results rhBMP-2/ACS = Autograft

rhBMP-2/ACS vs Autograft

rhBMP-2/ACS vs Autograft

Biomechanical Test Results

Rabbit Posterolateral Fusion Model

Strength of Bone Generated with rhBMP-2/ACS vs Autograft

rhBMP-2/ACS vs Autograft in Non-Human Primates

Preclinical Study Results (3 months)

Preclinical Study Results (6 Months)

rhBMP-2/ACS in Non-Human Primates

6 Month Fusion Results (%)

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InFUSE™ Bone Graft/LT-CAGE™ Pilot Clinical Study Design

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InFUSE™ Bone Graft/ LT-CAGE™ Device Human Pilot Study Results

InFUSE™ Bone Graft/LT-CAGE™ Device Pilot Study - Oswestry Results

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Goals of rhBMP-2/ACS Device

Conclusions -

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