Use of Proton Pump Inhibitors (PPIs) in Pediatric Patients (1996-2001)1

Drug

Number of Appearances2, 3

1996

1997

1998

1999

2000

2001

Total

1996-2001

Prilosec (omeprazole)

             

Total All Ages

6352

6891

8258

8145

7828

5176

42650

Age <1 yr

7

5

19

21

19

87

158

Age 1yr to <2 yrs

---

---

---

10

22

35

67

Age 2 yrs to <7 yrs

3

6

10

30

21

40

110

Age 7 yrs to <12 yrs

22

21

42

75

73

84

317

Age 12 yrs to <16 yrs

43

60

80

66

98

51

510

Total All Pediatric Ages

75

92

151

202

233

297

1162

Pediatric Use as Percent of Total for each year and for 1996-2001

1.2%

1.3%

1.8%

2.5%

3.0%

5.7%

2.7%

               

Prevacid (lansoprazole)

             

Total All Ages

1612

2610

4409

5992

6771

5782

27176

Age <1 yr

---

---

5

---

13

7

25

Age 1yr to <2 yrs

---

---

---

---

---

7

7

Age 2 yrs to <7 yrs

10

---

6

2

6

34

58

Age 7 yrs to <12 yrs

---

---

19

17

19

62

117

Age 12 yrs to <16 yrs

11

14

35

34

37

56

231

Total all Pediatric Ages

21

14

65

53

75

166

438

Pediatric Use as Percent of Total for each year and for 1996-2001

1.3%

0.5%

1.5%

0.9%

1.1%

2.9%

1.6%

               

Nexium (esomeprazole magnesium)

             

Total All Ages

---

---

---

---

---

2698

2698

Age <1 yr

---

---

---

---

---

0

0

Age 1yr to <2 yrs

---

---

---

---

---

0

0

Age 2 yrs to <7 yrs

---

---

---

---

---

6

6

Age 7 yrs to <12 yrs

---

---

---

---

---

13

13

Age 12 yrs to <16 yrs

---

---

---

---

---

10

10

Total all peds ages

---

---

---

---

---

29

29

Pediatric Use as Percent of Total

for each year and for 1996-2001

---

---

---

---

---

1.1%

1.1%

               

Protonix (pantoprazole sodium)4

             

Total All Ages

---

---

---

---

700

2354

3054

Age <1 yr

---

---

---

---

---

0

0

Age 1yr to <2 yrs

---

---

---

---

---

0

0

Age 2 yrs to <7 yrs

---

---

---

---

---

0

0

Age 7 yrs to <12 yrs

---

---

---

---

10

0

0

Age 12 yrs to <16 yrs

---

---

---

---

--

17

22

Total all peds ages

---

---

---

---

10

17

22

Pediatric Use as Percent of Total

for each year and for 1996-2001

---

---

---

---

1.4%

0.7%

0.7%

               

Aciphex (rabeprazole sodium)

             

Total All Ages

---

---

---

261

1995

2140

4396

Age <1 yr

---

---

---

---

---

0

0

Age 1yr to <2 yrs

---

---

---

---

---

0

0

Age 2 yrs to <7 yrs

---

---

---

---

---

2

2

Age 7 yrs to <12 yrs

---

---

---

---

2

3

5

Age 12 yrs to <16 yrs

---

---

---

3

10

13

52

Total all peds ages

---

---

---

3

12

18

59

Pediatric Use as Percent of Total

for each year and for 1996-2001

---

---

---

1.1%

0.6%

0.8%

1.3%

               

All PPIs

             

Total All Ages

7964

9501

12667

14398

17294

18150

79974

Age <1 yr

7

5

24

21

32

94

183

Age 1yr to <2 yrs

---

---

---

10

22

42

74

Age 2 yrs to <7 yrs

13

6

16

32

27

82

176

Age 7 yrs to <12 yrs

22

21

61

92

104

162

452

Age 12 yrs to <16yrs

54

74

115

103

145

147

825

Total all peds ages

96

106

216

258

330

527

1710

Pediatric Use as Percent of Total

for each year and for 996-2001

1.2%

1.1%

1.7%

1.8%

1.9%

2.9%

2.1%

1 IMS HEALTH, National Disease and Therapeutic Index™, January 1996 to June 2001, Excluding Long-Term Care Channel, drug uses, 4/2002.

[National Disease and Therapeutic Index ™ (NDTI) is a continuing survey designed and conducted by IMS HEALTH. This survey provides statistical information about the patterns and treatment of disease encountered in office-based practice in the continental United States. These data may include profiles and trends of diagnoses, patients, and treatment patterns].

2All numbers are in thousands (add three 0ís to each figure)

3 Please note that the sample sizes are small, particularly in the pediatric population and the data are projected to the national level by IMS HEALTH. Therefore, these data should be interpreted with caution and may not reliably distinguish meaningful differences.

4 Protonix use includes Protonix IV. There was no pediatric use of Protonix IV.

5/22/02 krs