MOA - PK Overview

5/16/02


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Table of Contents

MOA - PK Overview

Acamprosate

PPT Slide

Stages of Alcoholism Important for the Development of Animal Models

Effects of Acamprosate on Animal Models of Excessive Drinking

Protocol for Initiation of Lever Pressing for Oral Ethanol Self-Administration in the Rat

Blood Alcohol Levels in a Free-Choice Operant Task for Ethanol (10%) and Water Following the Saccharin Fade Out Procedure

Effects of Abstinence Interval on Alcohol Self-Administration

Chronic Acamprosate on Responding for Ethanol Following 5 Days Abstinence

What Acamprosate Does Not Do in Animal Models

Schematic Neuron Showing the Possible Mode of Action of Acamprosate on Alcohol-Related Effects

Neuropharmacological Effects of Acamprosate

Functional Significance of the Neuropharmacological Mechanism of Action of Acamprosate

Neuroprotective Effects of Acamprosate

Pre-Clinical and Clinical Pharmacokinetics of Acamprosate

Drug Interactions with Acamprosate

Schematic Neuron Showing the Possible Mode of Action of Acamprosate on Alcohol-Related Effects

Author: Maureen Galie