Triage test performance of HC 2 and cytology at different thresholds for detection of histologically confirmed CIN3 and CIN2 in the combined human papillomavirus (HPV) triage and immediate colposcopy arms

Positive Negative

Colposcopy predictive predictive

% sensitivity % referral value value

CIN3+

HC2† 96.3 56.1 10.0 99.5

HSIL+ cytology 44.1 6.9 37.5 96.5

LSIL+ cytology 64.0 26.2 14.3 97.1

ASCUS + cytology 85.3 58.6 8.5 97.9

CIN2+

HC2 95.9 56.1 19.6 98.9

HSIL+ cytology 34.8 6.9 58.1 92.0

LSIL+ cytology 59.2 26.2 25.9 93.6

ASCUS+ cytology 85.0 58.6 16.7 95.8

Solomon D, et al, 2001 JNCI 93(4):293-99