NORMAL AND NEOPLASTIC CELLULAR CHANGES WITHIN THE TRANSFORMATION ZONE

Normal Neoplastic Transforming Factors

Reserve Cell

l Cervical intraepithelial Neoplasia (CIN)

Reserve cell hyperplasia

l l l

immature atypical CIN 1_________

squamous immature : l

metaplasia metaplasia : regression

l l CIN 2

l l l

mature …………………. l ……..?………. CIN 3

squamous l

metaplasia Microinvasive

l Squamous carcinoma

stratified l

mature squamous Squamous carcinoma

epithelium

Wilkinson, 2001

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