Table of Contents
Clinical Management / Natural History of Cervical Dysplasia (CIN) and Related Findings
PPT Slide
PPT Slide
NORMAL AND NEOPLASTIC CELLULAR CHANGES WITHIN THE TRANSFORMATION ZONE
CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN):
The Bethesda 2001 System
Bethesda 2001 Cervical Cytology Classification
Bethesda 2001 Cervical Cytology Classification
COMPARISON OF THE WHO AND BETHESDA SYSTEM TERMINOLOGY
CAUSES OF NON-CORRELATION BETWEEN CYTOLOGY AND COLPOSCOPY
Specimen Adequacy
Other Non-Neoplastic Findings Optional to report; list not inclusive
Other
Atypical Squamous Cells (ASC)
ASC frequency and association with CIN
Sensitivity of a single repeat Pap test for detection of CIN 2 or CIN 3
ALTS: ASCUS Cytology Review
Ancillary Testing
PPT Slide
HPV Testing vs. Cervical Cytology / ASCUS and above
HPV Testing or Reflex to Colposcopy
Histology and Other Test Results for Women With an ASCUS Pap Test Result* N=973
Management of women with ASCUS (ASC) with HPV testing
Triage test performance of HC 2 and cytology at different thresholds for detection of histologically confirmed CIN3 and CIN2 in the combined human papillomavirus (HPV) triage and immediate colposcopy arms
ASC-H (cannot exclude HSIL): association with CIN 2 or CIN 3
MANAGEMENT OF ASC-H
PPT Slide
MANAGEMENT OF ASC-US
LSIL frequency and association with CIN
FOLLOW-UP: OBSERVATION VS. THERAPY
MANAGEMENT OF LSIL
HSIL frequency and association with CIN
MANAGEMENT OF HSIL
HPV results by HC 2
HIGH RISK HPV DETECTION
Risk of high-grade CIN in relation to time since first exposure to HPV 16
Pap test Results Preceding the Identification of women with CIN 2 or CIN 3
AGC frequency and association with CIN, Adenocarcinoma in situ (AIS) or Cervical or Endometrial Adenocarcinoma
Glandular Cell Abnormalities
Glandular Cell Abnormalities
AGC associated with CIN 2 or CIN 3
Cervical Adenocarcinoma Associated with HPV Types 16 and 18
MANAGEMENT OF AGC
Natural history of mild dysplasia (CIN 1)
Natural history of moderate dysplasia (CIN 2)
Natural history of CIS (CIN 3)
Natural history of CIN: summary
Regression
Progression
Invasive Cancer
MANAGEMENT OF CIN 1
FOLLOW UP FOR CIN 1
FOLLOW-UP: OBSERVATION VS. THERAPY
FOLLOW-UP: OBSERVATION VS. THERAPY
OBSERVATIONAL FOLLOW-UP, CIN 1
TREATMENT VS. OBSERVATION
TREATMENT VS. OBSERVATION
PPT Slide
TREATMENT OUTCOMES FOR CIN
METHODS TO TREAT CIN
RISK OF SIGNIFICANT HEMORRHAGE ASSOCIATED WITH TREATMENT FOR CIN
RESIDUAL CIN AFTER LEEP/CONE
MANAGEMENT OF CIN
CERVICAL CARCINOMA STAGING
Clinical Management / Natural History of Cervical Dysplasia (CIN) and Related Findings
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