PPT Slide
Above, right. CIN 3, cervix. Note adjacent koilocytes (bottom right). http://hsc.virginia.edu/med-ed/path/gyn/cervix4.html
Above, left. Squamous carcinoma in situ (CIS), cervix. To the right is normal squamous epithelium with its basal cell layer & orderly maturation upwards. The left side shows CIS characterized by lack of maturation, altered cell polarity, nuclear pleomorphism & increased nuclear / cytoplasmic ratio. As is characteristic of CIS, neoplastic cells are confined to the epithelial layer & have not invaded through the epithelial basement membrane, under which, the submucosal stroma contains chronic inflammatory cells.
Cornell Medical School http://www.pathinfo.com/alphlit.htm