Table of Contents
Review of Developmental Pharmacology
Goals of Presentation
The Developmental Continuum
Pharmacotherapy and the Developmental Continuum
What are the Key Developmental Issues Involved in Determining…
Acquisition of Functional Drug Biotransformation Activity
CYP3A7-CYP3A4 “Switch”
Phenytoin Elimination in Newborns
CYP1A2: Theophylline Metabolism
PPT Slide
Fractional Recovery of Major DM Metabolites
Metabolite “Shunting”
Potential Consequences of “Route Switching”
Potential Consequences of “Route Switching”
“Increased” Clearance or Metabolic Activity During Maturation
Distribution of Theophylline Dosage Requirements Milavetz et al. J. Pediatr. 109: 351-4, 1986
Cyclosporine Dosing in Children and Adults
CYP3A4 Activity in Children: Carbamazepine
Normalized S-Warfarin Clearance
Liver Mass:Body Weight Change with Age
Normalized Antipyrine Clearance Murry et al., Drug Metab Disp 23:1110, 1995
Points to Ponder
Summary
Acknowledgements
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Author: J.S. Leeder, PharmD, PhD
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