Use of animal models to assess safety
Studies to assess mobilization and
recombination with wild type HIV are difficult.
Appropriate animal model?
- HIV replicates, but is non-pathogenic in Chimpanzees
- Macaque model appropriate for SIV vector
- Murine model limited due to blocks in HIV replication
- SCID mouse models can serve as “in vivo test tube”, but replication still limited to human cells