Use of animal models to assess safety

• Studies to assess mobilization and

recombination with wild type HIV are difficult.

• Appropriate animal model?

  • HIV replicates, but is non-pathogenic in Chimpanzees
  • Macaque model appropriate for SIV vector
  • Murine model limited due to blocks in HIV replication
  • SCID mouse models can serve as “in vivo test tube”, but replication still limited to human cells

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