Lentiviral Vectors: Safety Issues

11/23/01


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Table of Contents

Lentiviral Vectors: Safety Issues

PPT Slide

PPT Slide

Lentiviral Vector Systems Under Development

Safety Concerns Specific to Lentiviral Vectors

Retroviral Recombination: Lessons Learned From Gammaretroviruses

PPT Slide

Retroviral Recombination: lessons learned from Gammaretroviruses

Retroviral Recombination: lessons learned from Gammaretroviruses

Vector Mobilization

Vector Mobilization

How to Address Safety Concerns With Lentiviral Vectors

1st Generation Lentivirus Vectors

1st Generation Vectors

2nd Generation Vectors

3rd Generation Vectors

Other Vector Developments

How to Address Safety Concerns With Lentiviral Vectors

Detection of Replication Competent Lentivirus (RCL)

Detection of Helper Sequences

Detection of Helper Sequences

How to Address Safety Concerns With Lentiviral Vectors

Use of animal models to assess safety

Clinical Monitoring

Lentiviral Safety Concerns: Conclusions

Lentiviral Safety Concerns: Conclusions

Author: Takefman