Measuring Normal Tissue Effects of Radionuclide Therapy

9/25/01


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Table of Contents

Measuring Normal Tissue Effects of Radionuclide Therapy

What is the Tolerance of Normal Organs to Radiation ?

Organ Tolerance Data Comparison

Organ Tolerance Data Comparison

Normal Organ Tolerance to Radiation (cGy)

Normal Organ Tolerance to Radiation (cGy)

Normal Organ Tolerance to Radiation (cGy)

How Accurate are Radionuclide Dose Estimates and Comparison Between Studies?

Radionuclide Dosimetry Is Less Accurate Than External Beam

How Accurate Are Tracer Studies?

Calculated Dose Is ? Biologic Dose

Biologic Factors Affecting Tolerance

PPT Slide

Biologic Effectiveness of Radionuclide Therapy

90Y-ChL6 Therapy of Breast Cancer Xenografts

How Accurate are Comparisons of Radionuclide Dose Estimates?

How Accurate are Comparisons of Radionuclide Dose Estimates?

How Accurate are Doses Reported -

When Does Imaging/Dosimetry Potential Have Great Impact ?

PPT Slide

PPT Slide

When Does Imaging/Dosimetry Potential Have Great Impact ?

Loculation, Then Resolved

Catheter Eroded into Bowel

RIT + External Beam RT

Myeloablative RIT + XRT

Tissue Tolerance to Re-Irradiation

Tolerance for 2nd Radiation Course - May be Close to that of Initial for Some Tissues

Radionuclide Re-treatment

Summary & Conclusions

Summary & Conclusions

Author: 345400