Entry Criteria

Age: 8 to 75 years

Etiology: Primary pulmonary hypertension

Collagen vascular disease

Congenital heart disease

NYHA class: II, III and IV

Hemodynamics: PAPm ? 25 mmHg

PVR > 3 Wood units

PCWP ? 15 mmHg

Walk distance: 50 to 450 meters

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