Severity of Elevated ALT/ASTSafety Database

?8

PAH (N = 165)

Others (N = 493)

All (N = 658)

ENABLE (N ? 807)*

4.2

3.9

4.0

2.8

1.8

3.2

2.9

2.0

12.7

10.8

11.2

8.6

ɯ - < 5

?5 - < 8

6.7

3.7

4.4

3.8

* Percentages assume all events occur on bosentan, as data are still blinded

ALT / AST (x ULN)

All

Database (%)

9091.01

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