Change in Hb ConcentrationNC15462 and NC15464B

Change from BaselineHb (g/dl)

Bosentan (n = 29) 500 mg bid

Placebo (n = 7)

BL

3

4

12

26

BL

12

Weeks

Weeks

Median and 25th and 75th percentiles

Bosentan (n = 29)

Bosentan (n = 7) 125 mg bid

NC15462 (REACH-1)

NC15464B (open label)

9083.01

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