Incidence of Decreased Hb ConcAC-052-351 and AC-052-352

Hemoglobin Conc (g/dl)

Chg to end of treatment

Chg to lowest value

% of Patients with

Decrease of ? 1.0 g/dl

Value < LLN

Marked decrease (LL)

LL and < 10.0 g/dl

?0.96

?1.09

34.8

13.8

1.8

1.2

0.01

?0.48

30.4

8.9

1.3

1.3

Placebo

(N = 79)

Placebo-subtracted

?0.96

?1.57

65.2

22.7

3.0

2.4

Bosentan

(N = 161)

LL = < 11.0 g/dl and ᡇ% decrease from baseline

9079.01

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