Incidence of Decreased Hb Conc8 Placebo-controlled Studies

Hemoglobin Conc (g/dl)

Chg to end of treatment

Chg to lowest value

% of Patients with

Decrease of ? 1.0 g/dl

Value < LLN

Marked decrease (LL)

LL and < 10.0 g/dl

?0.78

?0.77

27.8

7.5

3.1

0

?0.14

?0.55

29.0

24.4

2.6

2.2

Placebo

(N = 269)

?0.92

?1.32

56.8

32.0

5.6

2.2

Bosentan

(N = 618)

Placebo-subtracted

LL = < 11.0 g/dl and ᡇ% decrease from baseline

9078.01

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