Vital Signs

Change from BL

Pulse rate (bpm)

SBP (mmHg)

DBP (mmHg)Incidence

SBP < 80 mmHg

AE hypotension

Bosentan(N = 677)

?1.0 ? 1.1

?4.2 ? 1.4

?3.3 ? 1.0

Bosentan(N = 165)

Mean change ? SEM or percent

Placebo(N = 80)

0.2 ? 0.5

• 3.1 ? 0.7

• 3.0 ? 0.4

Placebo(N = 288)

0.3 ? 0.7

?2.4 ? 1.0

?0.4 ? 0.7

PC Studies

AC-052-351 + 352

3.3 ? 1.5

?3.8 ? 1.8

0.7 ? 1.2

2.8%

7.6%

0.8%

6.8%

0

3.8%

0.6%

6.7%

9067.01

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