AEs Leading to WithdrawalAC-052-351 and AC-052-352

Placebo

(N = 80)

Bosentan

(N = 165)

Abnormal hepatic func [n (%)]

Aggravated PAH

Cardiac failure

Syncope

Pts with ? 1 AE

Occurring in > 1 patient per treatment group

3 (1.8)

2 (1.2)

2 (1.2)

0

9 (5.5)

0

6 (7.5)

1 (1.3)

2 (2.5)

8 (10.0)

9064.01

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