AEs (? 1.0%) Leading to Withdrawal8 Placebo-controlled Studies

Abnormal hepatic func [n (%)]

Headache

Pts with ? 1 AE

Placebo

(N = 288)

2 (0.7)

2 (0.7)

27 (9.4)

28 (4.1)

8 (1.2)

75 (11.1)

Bosentan

(N = 677)

9063.01

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