Worsening Heart Failure
- Increased incidence of worsening HF during 1st month of treatment in CHF patients related to:
- Starting dose (125 and 250 mg bid)
- Speed of up-titration (weekly to 500 mg bid)
- Overall incidence of hospitalization for HF was significantly lower with bosentan vs placebo
64 (22.2%) 120 (17.7%)
60 (40.8%) 114 (38.9%)
- PC studies (288/677)
- CHF studies (147/293)