AEs of Specific Interest8 Placebo-controlled Studies

• Cardiac failure
• Dyspnea
• Aggravated PAH
• Angina pectoris/ chest pain

• Syncope
• Hypotension
• Postural hypotension
• Dizziness

All were more frequent among placebo-treated than bosentan-treated patients

• Abdominal pain / nausea / vomiting

9059.01

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