Exposure to Bosentan Overall and Placebo-controlled Studies
11 Therapeutic Studies
1200
1000
800
600
400
200
0
Days
0
25
50
75
100
Percent of Patients
All bosentan doses (N = 715)
Mean (SD): 168 ? 271 d
8 Placebo-controlled Studies
Days
Percent of Patients
4 weeks 526 (73.6%) 3 months 352 (49.2%) 6 months 141 (19.7%) 1 year 88 (12.3%)
3 years 28 (3.9%)
200
100
0
0
25
50
75
100
All bosentan doses (N = 677)
Placebo (N = 288)
Mean (SD): 101 ? 61 d
Mean (SD): 85 ? 64 d
50
150
9056.01
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