Subjects in the Database8 Placebo-controlled Studies

Indication [n (%)] PAH CHF HTN SAHTreatment Placebo Bos 100 mg/d

Bos 250-500 mg/d

Bos 1000-1500 mg/d

Bos 2000 mg/d

(28.8)(51.0) (17.0) (3.1)

(100)

(25.0)

(43.3) (28.7) (3.1)

(7.4)

(31.6)

(45.8)

(15.2)

Placebo (N = 288)

Bosentan (N = 677)

83

147  49

9

288

—

—

—

—

169

293 194  21

—

50

214

310

103

9055.01

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