Subjects in the Database

Pharmacology (23 studies)

Therapeutic trials
8 Placebo-controlled

3 Open-label (2 extensions)
ENABLE (blinded)

155

288

31

Placebo

Bosentan

434

677

91

1 : 1

All

571

965

122

1613

• About 1522 bosentan-treated patients
• Additional 62 PAH patients (ex-placebo) givenbosentan in AC-052-354

9054.01

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