6-minute Walk DistanceOpen-label Extension Study AC-052-353

Baseline (end of 351)

Change to Week 4*

393.8 ? 37.9

22.5 ? 14.3

Mean ? SEM in meters

Ex-placebo(n = 8)

Ex-bosentan(n = 21)

438.9 ? 14.2

3.0 ? 9.2

* Treatment in AC-052-351 still blinded for 26 of 29 patients

9044.01

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