Increase in Therapy for PAHAC-052-352 (Period 1)

% Pts with ? 1 increase

Treatment effect 95% CL

% Pts with ? 2 increases

Treatment effect 95% CL

Bosentan

(n = 144)

Placebo

(n = 69)

22.2

11.1

29.0

18.8

Period 1 was 16 weeks

?6.8 ?19.5, 7.1

?7.7 ?18.1, 4.7

9042.01

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