Changes in HemodynamicsChange to Week 12 (AC-052-351)

?12

?8

?6

?4

?2

0

2

?10

Mean PAP (mmHg)

PVR (dyn•sec/cm5)

Cardiac Index

(L/min/m2)

PCWP (mmHg)

Mean RAP (mmHg)

Mean (95% CL)

?6.7 (?11.9, ?1.5)

?415 (?608, ?221)

1.02 (0.65, 1.39)

?3.8 (?7.3, ?0.3)

?6.2 (?9.6, ?2.7)

?600

?400

?300

?200

?100

0

100

?500

Placebo = 10

Bos 125 mg bid = 20

?0.25

0.5

1

1.5

0

Placebo-corrected treatment difference

9041.01

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