Change in WHO ClassAC-052-351 and AC-052-352

Worsened 1 class (%)

No change

Improved 1 class

Improved 2 classes

Mann-Whitney U-test

0

57

43

0

6

64

30

0

2

56

38

4

Pbo(n = 11)

Change from BLto end of Period 1

Bos(n = 21)

18

73

9

0

Pbo(n = 69)

Bos(n = 144)

P = 0.019

P = 0.042

AC-052-351

AC-052-352

9040.01

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