Time to Clinical Worsening by DoseUp to Treatment End (AC-052-352)

Percent Event-free

Weeks

0

4

8

12

16

20

24

28

50

75

100

0

p = 0.01

p < 0.03

Bosentan

74

70

69

72

7068

18

1310

71

7063

70

6862

55

4848

14

117

7

63

Placebo

9037.01

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