Time to Clinical Worsening Up to Treatment End
Percent Event-free
Weeks
p < 0.01
50
75
100
Bosentan 125/250 mg bid
Placebo
p < 0.01
0
AC-052-352
p = 0.03
50
75
100
0
AC-052-351
144 69
142 68
31 10
141 63
138 62
103 48
25 7
13 3
Bosentan 125 mg bid
Placebo
21
11
21 11
7 1
21 10
21 8
12 4
6 1
2 1
9036.02
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