Change in Walk DistanceDuring Period 1

-10

0

20

40

60

Placebo (n = 11)

Bosentan 125 mg bid

(n = 21)

-10

0

20

40

60

Change in Walk Distance (m)

AC-052-352

AC-052-351

Mean ? SEM

62.5 mg bid

125 or 250 mg bid

Bosentan125/250 mg bid

(n = 144)

Placebo

(n = 69)

9030.01

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