Robustness of ResultsPrimary Parameter

AC-052-351

Mann-Whitney U-test

Per-protocol population

First 150 patients

Pts w/o Wk-16 endpoint

Carry forward

Zero substitution

Pbo CF, bos zero

Pbo exclude, bos zero

0.019

0.021*

—

0.041

—

—

—

AC-052-352

(0.0002)

0.0011

0.0063

0.0002

0.0008

0.0054

0.0176

P value

* Identical to ITT population

9029.01

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